Thomas R Webb Selected Research

5- ((4- (5- (7,7- dimethyl- 1,6- dioxaspiro(2.5)octan- 5- yl)- 3- methylpenta- 2,4- dien- 1- yl)cyclohexyl)amino)- 5- oxopent- 3- en- 2- yl methylcarbamate

1/2017	Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6.
8/2015	Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates.
12/2013	Optimization of antitumor modulators of pre-mRNA splicing.

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Thomas R Webb Research Topics

Disease

15	Neoplasms (Cancer) 01/2020 - 11/2005
6	Human Influenza (Influenza) 01/2021 - 01/2012
5	Pneumonia (Pneumonitis) 09/2007 - 10/2003
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020 - 01/2016
3	Pulmonary Fibrosis (Fibrosing Alveolitis) 09/2007 - 05/2006
2	Schistosomiasis (Bilharziasis) 12/2017 - 10/2014
2	Neuroblastoma 03/2009 - 10/2008
2	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 03/2009 - 02/2006
1	Heart Failure 01/2022
1	COVID-19 01/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2019
1	Drug-Related Side Effects and Adverse Reactions 01/2019
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2019
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Hypertension (High Blood Pressure) 10/2018
1	Virus Diseases (Viral Diseases) 12/2017
1	Diabetes Mellitus 01/2017
1	Myocardial Infarction 01/2016
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 09/2015
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 12/2014
1	Melanoma (Melanoma, Malignant) 12/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2009
1	Glioblastoma (Glioblastoma Multiforme) 03/2009
1	Histiocytosis 03/2009
1	B-Cell Lymphoma (Lymphoma, B Cell) 03/2009
1	Breast Neoplasms (Breast Cancer) 03/2009
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2009
1	Inflammation (Inflammations) 09/2007
1	Renal Cell Carcinoma (Grawitz Tumor) 11/2005

Drug/Important Bio-Agent (IBA)

7	Pharmaceutical PreparationsIBA 01/2021 - 11/2005
7	Proteins (Proteins, Gene)FDA Link 12/2017 - 03/2009
5	EndonucleasesIBA 01/2021 - 01/2012
4	QuartzIBA 09/2007 - 05/2006
3	RNA (Ribonucleic Acid)IBA 01/2021 - 06/2011
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 03/2009
3	RNA Precursors (Precursor, mRNA)IBA 01/2020 - 01/2017
3	LipidsIBA 01/2017 - 05/2006
3	5- ((4- (5- (7,7- dimethyl- 1,6- dioxaspiro(2.5)octan- 5- yl)- 3- methylpenta- 2,4- dien- 1- yl)cyclohexyl)amino)- 5- oxopent- 3- en- 2- yl methylcarbamateIBA 01/2017 - 12/2013
3	Anaplastic Lymphoma KinaseIBA 03/2009 - 02/2006
2	Praziquantel (Biltricide)FDA Link 12/2017 - 10/2014
2	sudemycin EIBA 12/2014 - 04/2014
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 03/2009 - 10/2008
2	Silicon Dioxide (Silica)FDA LinkGeneric 09/2007 - 10/2003
1	baloxavirIBA 01/2021
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2021
1	OligonucleotidesIBA 01/2021
1	FurinIBA 01/2020
1	Angiotensin-Converting Enzyme 2IBA 01/2020
1	Insulin (Novolin)FDA Link 01/2019
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2019
1	oxidized low density lipoproteinIBA 01/2019
1	Proprotein Convertase 9IBA 01/2019
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2019
1	CholesterolIBA 10/2018
1	VaccinesIBA 12/2017
1	Viral ProteinsIBA 12/2017
1	Deubiquitinating EnzymesIBA 10/2017
1	Viral RNAIBA 03/2016
1	Triglycerides (Triacylglycerol)IBA 01/2016
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2016
1	AngiopoietinsIBA 01/2016
1	P-2 (P 2)IBA 01/2016
1	ibrutinibIBA 09/2015
1	ChromatinIBA 04/2014
1	Zanamivir (Relenza)FDA Link 01/2014
1	Antiviral Agents (Antivirals)IBA 01/2014
1	Oseltamivir (Tamiflu)FDA Link 01/2014
1	Antineoplastic Agents (Antineoplastics)IBA 12/2013
1	Biological ProductsIBA 01/2013
1	MidkineIBA 03/2009
1	NucleophosminIBA 03/2009
1	Phosphotransferases (Kinase)IBA 03/2009
1	LigandsIBA 03/2009
1	Insulin ReceptorIBA 03/2009
1	pleiotrophin (HARP)IBA 03/2009
1	Small Interfering RNA (siRNA)IBA 10/2008
1	IronIBA 09/2007
1	titanium dioxide (Titania)FDA Link 01/2007
1	Quinacrine (Mepacrine)IBA 11/2005
1	Aminacrine (Aminoacridine)IBA 11/2005
1	NF-kappa B (NF-kB)IBA 11/2005
1	Nylons (Nylon)IBA 11/2003

Therapy/Procedure

10	Therapeutics 01/2022 - 02/2006
2	Drug Therapy (Chemotherapy) 08/2015 - 10/2008